Southeast Missouri Vacation Packages 2026 from $432

Southeast Missouri flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Motel 6 Rolla, MO

$432

per person

Jun 6 - Jun 11

found 1 day ago

Roundtrip non-stop flight included

Columbus (CMH) to St. Louis (STL)

A restaurant, free self parking, and a 24-hour front desk are among this motel's amenities. WiFi in public areas is free. A snack bar/deli is also provided.

Hermann Grain Bins BNB

Save 100% on your flight

$1,244

per person

Jun 6 - Jun 11

found 1 day ago

Roundtrip non-stop flight included

Columbus (CMH) to St. Louis (STL)

This bed & breakfast features free WiFi in public areas, barbecue grills, and free self parking. Enjoy the free full breakfast each morning. A garden and a picnic area are also provided.

Hilton St. Louis at the Ballpark

Downtown St. Louis

$859

per person

Jul 28 - Jul 31

found 21 hours ago

Roundtrip non-stop flight included

Seattle (SEA) to St. Louis (STL)

This smoke-free hotel includes 3 restaurants, an indoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Relax with a drink at one of the 3 bars/lounges and enjoy the a rooftop terrace.

21C Museum Hotel St Louis

Downtown West

$695

per person

Jul 28 - Jul 31

found 21 hours ago

Roundtrip non-stop flight included

Seattle (SEA) to St. Louis (STL)

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the gym and conveniences like a 24-hour front desk and concierge services.

Marriott St. Louis Airport

Edmundson

$780

per person

Jun 18 - Jun 22

found 6 hours ago

Roundtrip non-stop flight included

Albany (ALB) to St. Louis (STL)

This hotel features an indoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center, express check-in, and free airport shuttle. There's a bar/lounge on site, and laundry facilities and concierge services are also provided.

Top Southeast Missouri hotels deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$100 nightly

$113 total

May 10 - May 11

Total with taxes and fees

This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$109 nightly

$125 total

May 9 - May 10

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Free Cancellation

Reserve now, pay when you stay

$58 nightly

$64 total

Jun 1 - Jun 2

Total with taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$102 nightly

$115 total

May 17 - May 18

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. A 24-hour business center, a snack bar/deli, and express check-out are also on offer.

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3003 SOUTH OLD ORCHARD ROAD Jackson MO

Free Cancellation

Reserve now, pay when you stay

$98 nightly

$106 total

May 3 - May 4

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like self-serve breakfast and free self parking.

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$72 nightly

$81 total

May 17 - May 18

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. A safe deposit box is provided and the front desk is staffed around-the-clock.

Don't see what you're looking for?

See all available properties in Southeast Missouri

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just $432. Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.