Southeast Missouri Vacation Packages 2026 from $291

Southeast Missouri flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

Osage Village Inn

Save 100% on your flight

$291

per person

May 4 - May 11

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

An outdoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A lobby fireplace, express check-out, and luggage storage are also on offer.

The Wildwood Hotel

Save 100% on your flight

$903

per person

May 14 - May 18

found 23 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Lodge Of Four Seasons Golf Resort, Marina & Spa

Save 100% on your flight

$460

per person

May 4 - May 11

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

This resort features a golf course, a full-service spa, and a marina. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. You'll find 2 restaurants and 5 bars/lounges for dining and drinks, and an indoor pool is also on site.

Hotel Saint Louis, Autograph Collection

Downtown St. Louis

Save 100% on your flight

$588

per person

Apr 23 - Apr 26

found 7 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

This smoke-free hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. There's a bar/lounge on site, and laundry facilities and concierge services are also provided.

The Knight Center at Washington University

Save 100% on your flight

$467

per person

Mar 31 - Apr 4

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Self parking and a coffee shop are also offered on site.

Top Southeast Missouri hotels deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$100 nightly

$113 total

Feb 23 - Feb 24

Total with taxes and fees

This hotel features an indoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

The Riverview

777 Main St Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$94 nightly

$107 total

Feb 24 - Feb 25

Total with taxes and fees

This hotel features a casino and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. Relax with a drink at one of the 2 bars/lounges and enjoy perks like free self parking.

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Free Cancellation

Reserve now, pay when you stay

$54 nightly

$62 total

Feb 25 - Feb 26

Total with taxes and fees

This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

Free Cancellation

Reserve now, pay when you stay

$90 nightly

$102 total

Feb 25 - Feb 26

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and free perks like buffet breakfast and free self parking.

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$94 nightly

$108 total

Feb 23 - Feb 24

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3003 SOUTH OLD ORCHARD ROAD Jackson MO

Free Cancellation

Reserve now, pay when you stay

$84 nightly

$91 total

Feb 22 - Feb 23

Total with taxes and fees

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like self-serve breakfast and free self parking.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

An old granite quarry that has filled with water. An beautiful spring hike around the lake got me this picture

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just $291. Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.